RENFLEXIS contains the active ingredient, infliximab.
RENFLEXIS is a biosimilar medicine. Comparability in safety, efficacy and quality between RENFLEXIS and the reference product
has been established.
Infliximab is a monoclonal antibody that is produced from human and mouse proteins by recombinant technology. Monoclonal antibodies
are proteins that recognise and bind to certain special proteins in the body.
Infliximab acts by binding to a special protein in the body called tumour necrosis factor alpha (TNFα). In people with diseases
such as Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis,
the body produces too much TNFα, which can cause the body's immune system to attack normal healthy parts of the body. RENFLEXIS
can block the damage caused by too much TNFα.
Rheumatoid arthritis is an inflammatory disease of the joints. RENFLEXIS is used to reduce the signs and symptoms of rheumatoid
arthritis and to prevent damage to the joints. You will also be given a disease-modifying medicine called methotrexate.
Ankylosing spondylitis is an inflammatory disease of the spine. RENFLEXIS can reduce the signs and symptoms of ankylosing
spondylitis, thereby improving physical function.
Psoriatic arthritis is an inflammatory disease of the joints in which psoriasis usually occurs in association with arthritis.
Often the fingers and toes are affected, although it may occur in other parts of the body. RENFLEXIS is used to reduce the
signs and symptoms of psoriatic arthritis and improve the physical function in adults who have not responded well enough to
previous treatments with other disease-modifying anti-rheumatic drugs (DMARDS). RENFLEXIS may be given alone or in combination
Psoriasis is an inflammatory disease of the skin. RENFLEXIS is used to treat patients with moderate to severe psoriasis who
have not responded well enough to treatments such as phototherapy or conventional systemic treatments, or when these treatments
are not appropriate.
Crohn's disease is a chronic inflammatory disease of the bowel. It may also affect any part of the gut. RENFLEXIS is used
to treat moderate to severe Crohn's disease in adult patients and in children and adolescent patients (6 to 17 years old)
who have not responded well enough to other treatments.
RENFLEXIS can also reduce the number of abnormal openings from the bowel through the skin (called draining enterocutaneous
fistula), a common complication of Crohn's disease.
Ulcerative colitis is an inflammatory disease of the bowel. RENFLEXIS is used to treat the signs and symptoms of ulcerative
colitis in adult patients and in children and adolescent patients (6 to 17 years old) who have not responded well enough to
Do not give RENFLEXIS to children with Crohn's disease or ulcerative colitis who are younger than 6 years.
Do not give RENFLEXIS to children and adolescents with any other disease.
Your doctor, however, may prescribe RENFLEXIS for another purpose.
Ask your doctor if you have any questions about why RENFLEXIS has been prescribed for you.